京都府立医科大学 眼科学教室

Corneal Cell Biology / Wound Healing and Cytokines

研究実績

Publications 1992-1997
( Original and Collaborated Achievements )

Corneal Cell Biology / Wound Healing and Cytokines




































































































































Immunohistochemical localization of transforming growth factor‐β1, ‐β2, ‐β3 latency‐associated peptide in human cornea.

Invest Ophthalmol Vis Sci 35:3289‐3294,1994. (Nishida K, Kinoshita S, Yokoi N, Kaneda M, Hashimoto M, Yamamoto S)

* TGF‐β2 is predominately expressed in corneal epithelium and stroma, which suggests an important role for the maintenance of cornea.

 
Transforming growth factor‐β1, ‐β2, ‐β3 mRNA expression in human cornea.

Curr Eye Res 14(3):235‐241,1995. (Nishida K, Sotozono C, Yokoi N, Kinoshita S)
 
High latent TGF‐ β2 levels in normal human tears.

Curr Eye Res 15:341‐343,1996. (Kokawa N, Sotozono C, Nishida K, Kinoshita S)
 
Effect of transforming growth factor‐β1 and ‐β2 on in vitro rabbit corneal epithelial cell proliferation promoted by epidermal growth factor, keratinocyte growth factor, or hepatocyte growth factor.

Exp Eye Res 65:391‐396,1997. (Honma Y, Nishida K, Sotozono C, Kinoshita S)
 
Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth.

Exp Eye Res 59:385‐392,1994. (Sotozono C, Kinoshita S, Kita M, Imanishi J)

* KGF enhances the proliferation of cultured rabbit corneal epithelial cells as a paracrine mediator, but not keratocytes.

 
Expression of keratinocyte growth factor mRNA in ex vivo and in vitro specimens of human cornea and conjunctiva.

Jpn J Ophthalmol 38:353‐359,1994. (Sotozono C, Kinoshita S, Kita M, Imanishi J)
 
Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo.

Invest Ophthalmol Vis Sci 36(8):1524‐1529,1995. (Sotozono C, Inatomi T, Nakamura M, Kinoshita S)

* Topical application of KGF accelerates corneal epithelial wound healing in vivo, and increases cell proliferation in the limbal epithelium of the regenerating cornea.

 
Cytokine expression in the alkali‐burned cornea.

Curr Eye Res 16:670‐676,1997. (Sotozono C, He J, Matsumoto Y, Kita M, Imanishi J, Kinoshita S)

* Among the ten cytokines examined, IL‐1a and IL‐6 are strongly induced in the early stages of alkali burn, and both are mainly localized in regenerating epithelial basal cells.

 
Enhancement of growth of rabbit corneal endothelial cells by PDGF.

Cornea 14(2):187‐195,1995. (Kamiyama K, Iguchi I, Wang X, Kita M, Imanishi J, Yamaguchi N, Hongo M, Sotozono C, Kinoshita S)
 
Enhancing effect of platelet‐derived growth factors on migration of corneal endothelial cells.

Cornea 14(4):365‐371,1995. (Iguchi I, Kamiyama K, Wang X, Kita M, Imanishi J, Yamaguchi N, Hongo M, Sotozono C, Kinoshita S)
 
Distribution of epidermal growth factor in rat ocular and periocular tissues.

Graefe’s Arch Ophthalmol 231:228‐232,1993. (Watanabe H, Ohashi Y, Kinoshita S, Manabe R, Oshiden S)
 
Messenger RNA expression of heat shock proteins (HSPs) during ocular development.

Curr Eye Res 14(12):1125‐1133,1995. (Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J)
 
Expression of 47‐kDa heat shock protein (HSP47) during development of mouse cornea.

Exp Eye Res 63:383‐ 393,1996. (Tanaka Y, Kobayashi K, Kita M, Masuda H, Kinoshita S, Nagata K, Imanishi J)
 
Herpes simplex virus‐induced expression of 70 kDa heat shock protein (HSP70) requires early protein synthesis but not viral DNA replication.

Microbiol Immunol 38(4):321‐325,1994. (Kobayashi K, Ohgitani E, Tanaka Y, Kita M, Imanishi J)
 
Epithelial wound healing in the denervated cornea.

Curr Eye Res 13:203‐211,1994. (Araki K, Ohashi Y, Kinoshita S, Hayashi Y, Kuwayama Y, Tano Y)
 
Immortalization of rabbit corneal epithelial cells by a recombinant SV 40‐adenovirus vector.

Invest Ophthalmol Vis Sci 34:2665‐2671,1993. (Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang XZ, Hosaka Y, Aizawa S, Honda H )
 
Effects of topical aldose reductase inhibitor CT‐112 on corneal sensitivity of diabetic rats.

Curr Eye Res 15:1005‐1007,1996. (Hosotani H, Ohashi Y, Kinoshita S, Matsumoyo T, Awata T)
 
Distribution of endothelin and endothelin‐A receptor in the lacrimal glands of the monkey (Macaca fuscata).

Exp Eye Res 64:127‐132,1997. (Niiya A, Matsumoto Y, Ishibashi T, Matsumoto K, Kinoshita S)
 
Collagen gel‐embedding culture of conjunctival epithelial cells.

Graefe’s Arch Ophthalmol 235: 32‐40,1997. (Matsumoto Y, Ishibashi T, Niiya A, Yamada H, Kurokawa K, Kinoshita S)