京都府立医科大学 眼科学教室

Corneal Immunology and Transplantation

研究実績

Publications 1992-1997
( Original and Collaborated Achievements )

Corneal Immunology and Transplantation












































































Effects of suture‐induced corneal neovascularization on the ocular immunosuppressive microenvironment.

Regional Immunolgy Proceedings for the Third International Symposium on Recent Development in the Immunopathology and Intraocular Inflammation 6:173‐176,1994. (Sano Y, Streilein JW)
 
Characterization of cell‐mediated immune responses elicited by orthotopic corneal allografts in mice.

Invest Ophthalmol Vis Sci 36(2):427‐434,1995. (Sonoda Y, Sano Y, Ksander B, Streilein JW)
 
Fate of orthotopic corneal allografts in eyes that cannot support anterior chamber‐associated immune deviation induction.

Invest Ophthalmol Vis Sci 36(11):2176‐2185,1995. (Sano Y, Ksander BR, Streilein JW)

* Allograft rejection in high‐risk eyes correlates with recipient acquisition of donor‐specific delayed hypersensitivity response which is directed only at minor alloantigens.

 
Immunosuppressive properties of tissues obtained from eyes with experimentally manipulated corneas.

Invest Ophthalmol Vis Sci 37 (2):413‐424,1996. (Streilein JW, Bradley D, Sano Y, Sonoda Y)

* Corneal neovascularization or Langerhans migration into central cornea robbs eyes of their immunosuppressive properties which inhibited destructive immune response.

 
Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice.

Transplant Immunol 4:53‐56,1996. (Sano Y, Ksander BR, Streilein JW)
 
Role of donor‐specific cyototoxic T cells in rejection of corneal allografts in normal and high‐risk eyes.

Transplant Immunol 4:49‐52,1996.(Ksander BR, Sano Y, Streilein JW)

* Cytotoxic T cell activity against minor alloantigens, but not MHC alloantigens is responsible for graft rejection.

 
Immunosuppressive properties of tissues of the ocular anterior segment.

Ocular Immunology and Inflammation4(1):57‐68,1996. (Streilein JW, Bradley D, Sano Y)
 
Murine orthotopic corneal transplantation in high‐risk eyes.

Invest Ophthalmol Vis Sci 38 (6):1130‐1138,1997. (Sano Y, Ksander BR, Streilein JW)
 
Induction of donor‐specific ACAID can prolong orthotopic corneal allograft survival in "high‐risk" eyes.

Curr eye Res 16: 1171‐1174, 1997. (Sano Y, Okamoto S, Streilein JW)

* Induction of donor‐specific ACAID, which suppressed delayed hypersensitivity, prevents graft rejection in high‐risk eyes.

 
ACAID induction by corneal allografts placed in the anterior chamber.

Invest Ophthalmol Vis Sci 38(13):2833‐2843,1997. (Yamada J, Streilein JW)
 
Topical IL‐1 receptor antagonist promotes corneal transplant survival.

Transplantation 63(10): 1501‐1507,1997. (Dana MR, Yamada J, Streilein JW)