京都府立医科大学 眼科学教室

Retinal Cell and Molecular Biology

研究実績

Publications 1992-1997
( Original and Collaborated Achievements )

Retinal Cell and Molecular Biology


























































































Nerve growth factor:a mitogenic signal for retinal Mu245Dller glial cells.

Brain Res 649:260‐264,1994. (Ikeda T, Puro DG)

* Human Muller glial cells in culture express functional NGF receptors and the response of Muller cells to NGF can be modulated by other growth factors.

 
Truncated of IGF‐I yields two mitogens for retinal Mu245Dller glial cells.

Brain Res 686:87‐92,1995. (Ikeda T, Puro DG)
 
Regulation of retinal glial cell proliferati on by antiproliferative molecules.

Exp Eye Res 60(4):435‐444,1995. (Ikeda T, Puro DG)

* TGF‐β2 may selectively inhibit retinal glial mitogenesis mediated by activation of tyrosine kinase type growth factors, such as bFGF, PDGF, EGF,IGF‐1.

 
Isolation and chromosomal localization of the human cone cGMP phosphodiesterase cDNA (PDE6H).

Genomics 32:121‐124,1996. (Shimizu‐Matsumoto A, Itoh K, Inazawa J, Nishida K, Matsumoto Y, Kinoshita S, Matsubara K, Okubo K)

* Gene expression profile of human retina is reported. The human cone cGMP phosphodiesterase cDNA, which is one of the retina specific genes was cloned.

 
An expression profile of genes in human retina and isolation of a complementary DNA for a novel rod photoreceptor protein.

Invest Ophthalmol Vis Sci 38(12):2576‐2585,1997. (Shimizu‐Matsumoto A, Adachi W, Mizuno K, Inazawa J, Nishida K, Kinoshita S, Matsubara K, Okubo K)
 
Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells.

Biochem Biophys Res Commun 236(3):712‐715,1997. (Hirata C, Nakano K, Nakamura N, Kitagawa Y, Shigeta H, Hasegawa G, Ogata M, Ikeda T, Sawa H, Nakamura K, Inenaga K, Obayashi H, Kondo M)

* Elevation of AGEs in the vitreous may promote intraocular neovascularization in diabetic retinopathy through production of VEGF from Muller cells.

 
A culture model of development reveals multiple properties of RPE tight junctions.

Molecular Vision 3:18,1997. (Ban Y, Rizzolo LJ)
 
Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma.

Cancer Genet Cytogenet 98:43‐49,1997. (Ohtani‐Fujita N, Dryja TP, Rapaport JM, Fujita T, Matsumura S, Ozasa K, Watanabe Y, Hayashi K, Maeda K, Kinoshita S, Matsumura T, Ohnishi Y, Hotta Y, Takahashi R, Kato MV, Ishizaki K, Sasaki MS, Horsthemke B, Minoda K, Sakai T)
 
Detecting herpesvirus DNA in uveitis of unknown etiology using the polymerase chain reaction.

Br J Ophthalmol 80:465‐468,1996. (Yamamoto S, Pavan‐Langston D, Kinoshita S, Nishida K, Shimomura Y, Tano Y)
 
Retinal detachment after branch retinal vein occlusion: influence of the type of break on the outcome of vitreous surgery.

Ophthalmology 104(1):27‐32,1997. (Ikuno Y, Tano Y, Lewis JM, Ikeda T, Sato Y)

* The authors describe surgical results of vitrectomy for RRD after BRVO and investigate whether there is any difference between clinical features or surgical results from eyes with the two types of retinal breaks.

 
Exotropia secondary to vitreous hemorrhage.

Graefe’s Arch Clin Exp Ophthalmol 235:143‐148,1997. (Fujikado T, Ohmi G, Ikeda T, Lewis JM, Tano Y)
 
Spontaneous disappearance of traumatic macular holes in young patients.

Am J Ophthalmol 123(6):837‐839,1997. (Kusaka S, Fujikado T, Ikeda T, Tano Y)
 
Subretinal hemorrhage after granulocyte colony‐stimulating factor.

Lancet 350(9074):336,1997. (Matsumura T, Maruyama‐Tabata H, Kuwahara Y, Sawada T, Ikeda T)